Issue 2, 2006

Acetylcholinesterase inhibitors from plants and fungi

Abstract

Covering: January 1980 to August 2005

This review describes 183 compounds obtained from plants and fungi which have been shown to inhibit acetylcholinesterase. The mechanism of action of cholinesterase, together with the binding sites, and, where this is known, the mode of action of inhibitors is described. The relative activities of the different compounds are recorded. The strongest inhibitors are generally alkaloids although some meroterpenoids from fungi have also been found to be active and display better selectivity.

Graphical abstract: Acetylcholinesterase inhibitors from plants and fungi

Article information

Article type
Review Article
Submitted
20 Dec 2005
First published
01 Feb 2006

Nat. Prod. Rep., 2006,23, 181-199

Acetylcholinesterase inhibitors from plants and fungi

P. J. Houghton, Y. Ren and M. Howes, Nat. Prod. Rep., 2006, 23, 181 DOI: 10.1039/B508966M

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